There is a lot of nonsense out in the webosphere about cleanses and detoxing, but the one organ that can benefit from the occasion house cleaning is the hard working liver. There are lots of reasons for doing a cleanse or detox particularly if you drink a lot of alcohol, caffeine, or eat many carbs. My spouse and I occasionally do a two week detox, which is simply eating a low carb, high fat clean diet, and abstaining from alcohol and, hardest of all for many, caffeine. For extra benefits, use protein shakes for two meals a day.
If your caffeine habit is hard core, then you might want to spend a week slowly reducing the number of cups of coffee you drink (same for alcohol and high carbs–especially after a binge) before total elimination which will help to ease headaches which frequently go along with the detoxing.
The liver is prone to developing excess fat when abused, especially by alcohol and high carbohydrates (worse if they are the junk sugars and starches), which can lead to poor functioning, and in the case of alcohol to the disease cirrhosis.
Plus, you might lose a pound or two if that matters.
Yours in cleaning house,
Nan aka Sugarbaby